Literature Review

A workflow initiative to increase the early palliative care referral rate in patients with advanced cancer MDedge - Federal Practitioner - Quality Improvement; by Judy Lim, MD and Linda D. Nguyen, DNP, NP-C, MD; 9/3/25 ... The American Society of Clinical Oncology and the World Health Organization recommend that every patient with advanced cancer should be treated by a multidisciplinary palliative care team early in the course of the disease and in conjunction with anticancer treatment. Despite the documented benefits and the recommendations, early PC is still not often offered in clinical practice. 

How to move a parent with dementia against family resistance—and stay legal Advisorpedia; by Carolyn Rosenblatt; 9/3/25 The phone call came to Dad’s daughter (FD) at 6 AM. Again. This time, it was the night caregiver reporting that her father had fallen while trying to get out of bed. She had jumped up and tried to stop him but she could only get to him in time to break his fall. ... The caregiver was exasperated. She needed more help and SW did not provide it. It was the third incident in two weeks, and FD knew something had to change.

Palliative care use and end-of-life care quality in HR+/HER2- metastatic breast cancerBreast Cancer Research and Treatment; by Julia G Cohn, Susan C Locke, Kris W Herring, Susan F Dent, Thomas W LeBlanc; 8/25Metastatic breast cancer (MBC) is incurable, despite therapeutic advances, especially in hormone receptor positive (HR+) and human epidermal growth factor-2 negative (HER2-) disease. Of 102 patients, 85 died during the study period, and over half (55%) received aggressive EoL [end of life] care. Half had some form of SPC [specialist palliative care], and rates of aggressive EoL care were comparable between those who engaged with SPC and those who did not. The most common indicators of aggressive EoL care included multiple ED visits (28%) and hospital admissions (23%) in the last 30 days of life as well as in-hospital location of death (24%). Although 72% enrolled in hospice care, 9% of patients were on hospice for ≤ 3 days. This real-world study demonstrates that many patients with HR + /HER2- MBC [metastatic breast cancer] receive aggressive EoL care despite some engaging with SPC and many enrolling in hospice. 

Palliative care and liver disease: Understanding hepatitis and beyond Ashland LocalTownPages, Aubrey, TX; by Press Services; 9/1/25 Sovereign Hospice, a woman-led hospice care provider serving the Dallas-Fort Worth Metroplex, offers specialized liver disease support programs. The organization also provides targeted hospice home care services and palliative care programs designed specifically for patients facing hepatitis and other advanced liver conditions throughout North Texas.

[Iceland] Medication causes and treatment of delirium in patients with and without dementiaBrain and Behavior; by Anita Elaine Weidmann, Rut Matthíasdóttir, Guðný Björk Proppé, Ivana Tadić, Pétur Sigurdur Gunnarsson, Freyja Jónsdóttir; 7/25This summary offers the most detailed summary of medication-related information for delirium in patients with and without dementia to support prescribing decisions. While the detailed results can be used to support a multicomponent approach to delirium care, they also support the call for categorizing delirium into distinct etiological subgroups. The effect of medication on gut microbiome diversity and composition should be considered.

Unity Hospice receives $20,000 from the Jerry Parins Cruise for Cancer The Chamber - Manitowoc County, De Pere, WI; Press Release; 8/18/25 For the tenth consecutive year, Unity Hospice has been chosen as a recipient of funds from the Jerry Parins Cruise for Cancer. These contributions help Unity provide compassionate hospice care, palliative care, and grief support to individuals and families across Northeast Wisconsin. The Jerry Parins Cruise for Cancer, a motorcycle ride to benefit cancer patients and families throughout Northeastern Wisconsin, presented checks totaling $185,000 to eleven local cancer support organizations at Vandervest Harley-Davidson.

This test tells you more about your heart attack risk KFF Health News; by Paula Span; 8/1/25 A long list of Lynda Hollander’s paternal relatives had heart disease, and several had undergone major surgeries. ... A cardiologist told Hollander that based on factors like age, sex, cholesterol, and blood pressure, she faced a moderate risk of a major cardiac event, like a heart attack, within the next 10 years. ... Her doctor explained that a coronary artery calcium test, ... could provide a more precise estimate of her risk of atherosclerotic heart disease. “The test is used by more people every year,” said Michael Blaha, co-director of the preventive cardiology program at Johns Hopkins University. Calcium scans quadrupled from 2006 to 2017, his research team reported, and Google searches for related terms have risen even more sharply. Yet “it’s still being underused compared to its value,” he said. One reason is that although the test is comparatively inexpensive ...Editor's Note: Good news. This test predicts and protects heart health, potentially providing extra years of good (or at least better) quality of life. Bad news. It is "being underused compared to its value," partly because "the test is comparatively inexpensive"? Bad news. What does the low-cost factor say ethics, choices, and quality of life? Good news. Because of my family's cardiac history, my physician recently recommended I take this test. I did, and received great results! I move into the future with greater confidence, less fear, and more gratitude for the some 100,00 heartbeats we each experience, each day.

Sex and racial/ethnic differences in end-of-life care in decedents with lung cancer in TexasJournal of Palliative Medicine; by Myrna Katalina Serna, Efstathia Polychronopoulou, Aimee Rodriguez, Anjali Ramachandran, Margaret Goodrich, Sean O'Mahoney, Mukaila Raji, Yong-Fang Kuo; 7/25The lung cancer five-year survival rate is lower for Texans compared with the national average. We assessed sex and racial/ethnic differences in end-of-life care among decedents with lung cancer in Texas [and found that] ... males had more health care utilization and less hospice enrollment. Non-Hispanic Blacks and Hispanics had more health care utilization and less hospice enrollment ... Billed ACP [advance care planning] was low across all groups.

Ethics of overtreatment and undertreatment in older adults with cancerBMC Medical Ethics; by Clark DuMontier, William Dale, Anna C. Revette, Jane Roberts, Ameya Sanyal, Neha Perumal, Eric C. Blackstone, Hajime Uno, Mary I. Whitehead, Lewis Mustian, Tammy T. Hshieh, Jane A. Driver, Gregory A. Abel; 7/25This modified Delphi study convened a panel of experts in biomedical ethics and reached consensus that the principles of beneficence, non-maleficence, and autonomy are related to our previously proposed definitions of over- and undertreatment in older adults with cancer. The panel also reached consensus that, in most cases, it is unethical to make a treatment recommendation without (1) formal assessment of patient frailty (e.g., via a geriatric assessment) and (2) the opportunity for a patient to share their values, goals, and/or preferences. The panel did not reach consensus regarding the relationship between justice and over-/undertreatment; however, the panel concluded that justice applies to undertreatment when an oncologist withholds potentially beneficial cancer treatment in an older patient based on their age alone.

The heart of transformation: People, purpose and progress at City of Hope Modern Healthcare; by City of Hope; 7/14/25 As chief transformation officer at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S., Debra Fields has spent nearly a decade guiding the organization’s evolution. In this conversation, Fields shares her perspective on what it takes to lead meaningful transformation in healthcare including the power of vision, the importance of culture and the responsibility leaders have to care for both their people and themselves.

The treatment of chemotherapy-induced peripheral neuropathy: A review of current management options and a potential role for scrambler therapyFrontiers in Pain Research; by Hassan Aboumerhi, Henry Vucetic, Andrew Gruenzel, Bahar Moftakhar, Mona Gupta, Santosh K Rao, Michael D Staudt; 7/25Chemotherapy-induced peripheral neuropathy (CIPN) presents a growing medical and financial burden on patients and the healthcare system alike. This has been treated with conservative and interventional care limited by efficacy, side effects, and lack of coverage. As such, there is an unmet treatment need for effective non-invasive or minimally invasive therapies for the treatment of CIPN. Scrambler therapy (ST) is a peripheral, non-invasive neuromodulation technique, which uses transcutaneous electrical stimulation to modulate pain signals. ST has shown mixed results in clinical trials; while some patients report symptom relief, more robust evidence is required before it can be widely recommended.

Doctors’ own end-of-life choices defy common medical practice Medscape; by Cristina Ferrario; 7/29/25 A new survey revealed that most doctors would decline aggressive treatments, such as cardiopulmonary resuscitation (CPR), ventilation, or tube feeding for themselves if faced with advanced cancer or Alzheimer’s disease, choosing instead symptom relief and, in many cases, assisted dying. ... The researchers conducted a cross-sectional survey of 1157 physicians, including general practitioners, palliative care specialists, and other clinicians from Belgium, Italy, Canada, the US, and Australia. ... Over 90% preferred symptom-relief medication, and more than 95% declined CPR, mechanical ventilation, or tube feeding. Only 0.5% would choose CPR for cancer and 0.2% for Alzheimer’s disease. Around 50%-54% supported euthanasia in both cases.

My mother refused treatment for her breast cancer. Her doctors should have respected her choice. Instead they dismissed her--and criticized me.STAT; by Joy Lisi Rankin; 7/21/25My mother died in January 2007. She told the family that she had breast cancer in 2002. We still don’t know when she knew, or when she had been diagnosed. One thing we did know: She chose not to treat the cancer. In her encounters with health care professionals — doctors, nurses, assistants — during the last years of her life, her choice was met with disbelief and disdain. “Why aren’t you treating your cancer?” “Do you understand what’s going to happen?” “You know you’re going to die, right?” A final thought went unsaid but was clear: “If you’re not going to do what I recommend, I can’t do anything for you.” [Limited access to STAT with three stories per month.]