Literature Review

All posts tagged with “Research News.”



Calibrating AI reliance—A physician’s superhuman dilemma

04/26/25 at 03:45 AM

Calibrating AI reliance—A physician’s superhuman dilemmaJAMA Health Forum; Shefali V. Patil, PhD; Christopher G. Myers, PhD; Yemeng Lu-Myers, MD, MPH; 3/25Assistive artificial intelligence (AI) technologies hold significant promise for transforming health care by aiding physicians in diagnosing, managing, and treating patients. Leveraging AI’s superior diagnostic accuracy in certain specialties, these assistive AI systems aim to reduce medical errors, while also promising to address physician fatigue by alleviating cognitive load and time pressures. Because human operators are perceived as having control over the technology’s use, responsibility unduly shifts to the human operator, even when clear evidence shows that the AI system produces erroneous outputs. Consequently, although scholars have proposed recommendations for shaping AI regulations, the reality is that in the absence of clear policies or established legal standards, future liability will largely hinge on societal perceptions of blameworthiness. This regulatory gap imposes an immense, almost superhuman, burden on physicians: they are expected to rely on AI to minimize medical errors, yet bear responsibility for determining when to override or defer to these systems.

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Kidney transplant fast track and likelihood of waitlisting and transplant-A nonrandomized clinical trial

04/26/25 at 03:40 AM

Kidney transplant fast track and likelihood of waitlisting and transplant-A nonrandomized clinical trialJAMA Internal Medicine; Larissa Myaskovsky, PhD; Yuridia Leyva, MS; Chethan Puttarajappa, MD; Arjun Kalaria, MD; Yue-Harn Ng, MD; Miriam Vélez-Bermúdez, PhD; Yiliang Zhu, PhD; Cindy Bryce, PhD; Emilee Croswell, BA; Hannah Wesselman, PhD; Kellee Kendall, MPH; Chung-Chou Chang, PhD; L. Ebony Boulware, MD; Amit Tevar, MD; Mary Amanda Dew, PhD; 3/25Although it is a seemingly intuitive solution to enabling more patients to complete the evaluation process and be added to the waitlist, to our knowledge, few transplant centers use a health care system–facilitated approach like KTFT [Kidney Transplant Fast Track]. In this nonrandomized clinical trial of 1,118 patients with end-stage kidney disease (ESKD) who underwent KTFT and a historical control group of 1,152 patients with ESKD undergoing evaluation for kidney transplant, the KTFT group had a higher likelihood of waitlisting and transplant than the historical control group. Unlike the historical control group, the KTFT group had no significant differences in kidney transplant by race or ethnicity.

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Opening the door to wholistic patient care: Results from a nationally representative database on the use of spiritual and religious counseling

04/26/25 at 03:35 AM

Opening the door to wholistic patient care: Results from a nationally representative database on the use of spiritual and religious counselingHealth Services Insights; Peter J. Mallow, Pierson Savarino; 4/25The introduction of the International Classification of Diseases 10th Revision (ICD-10) code Z71.81 in 2015 enabled the systematic documentation of spiritual and religious counseling (SRC) in hospital settings, opening avenues for research into its effect on patient outcomes and healthcare resource utilization. Religion and spirituality are integral to many patients’ lives, influencing their well-being, recovery and health outcomes. SRC is primarily utilized in complex, high-mortality cases, underscoring its role in holistic care for severely ill patients. The disparities observed highlight the need for standardized SRC documentation and equitable access to SRC. Future research should investigate the clinical and economic impacts of SRC to enhance patient-centered care in alignment with value-based care practices.

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Circadian rhythm in end-of-life delirium: a secondary analysis of two randomized controlled trials

04/26/25 at 03:15 AM

Circadian rhythm in end-of-life delirium: a secondary analysis of two randomized controlled trials Journal of Pain and Symptom Management; Sonal Admane MD, MPH; Sarah Pasyar MS; Roland Bassett Jr. MS; Eduardo Bruera MD; David Hui MD, MSc; 4/25Over 90% of patients with advanced cancer in the last weeks and days of life experience delirium, a neurocognitive syndrome associated with increased restlessness, agitation, hallucinations, and even violent behaviors. Long term psychological morbidity is also seen in caregivers, who may develop prolonged grief, anxiety, and post-traumatic stress disorder. Healthcare professionals caring for patients with delirium also report delirium-related distress, particularly in relation to patients with persistent restlessness and agitation. Delirious patients were more restless between 3 pm and 11 pm. This observation of “sundowning” may help clinicians to better anticipate this symptom, schedule monitoring and treatments, and educate patients and caregivers.

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Assuring the provision of palliative care as an ethical duty for all physicians

04/26/25 at 03:10 AM

Assuring the provision of palliative care as an ethical duty for all physiciansJournal of Pain and Symptom Management; Amber R Comer,Daniel Sulmasy; 4/25Although palliative care is an evidence-based, essential component of care for patients with serious or critical illness and at the end-of-life, access to palliative care continues to be limited by inaccurate definitions, misrepresentation, stigma, and neglect. To help physicians and patients to overcome barriers limiting the provision of palliative care, the American Medical Association (AMA) has recently adopted policy and a new opinion in the Code of Medical Ethics which establishes an ethical duty for all physicians, in all specialties, to assure the provision of palliative care to patients who stand to benefit. Additionally, the new policy and Code opinion expand the depth and breadth of what palliative care access and delivery entail and address misconceptions that have resulted in barriers to the delivery of palliative care.

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Medical aid in dying in the state of Colorado: Perspectives, data, and lessons learned in the first years of a uniquely centralized program

04/26/25 at 03:05 AM

Medical aid in dying in the state of Colorado: Perspectives, data, and lessons learned in the first years of a uniquely centralized programJournal of Palliative Medicine; Melanie Mandell, Katie Sue Van Valkenburg, Skye O’Neil, Genie E. Roosevelt, Kerri Mason; 4/25 In 2016, Colorado voters approved Proposition 106, “Access to Medical Aid in Dying,” which amended Colorado statutes to include the Colorado End-of-life Options Act. In 2018, Denver Health and Hospital Authority, an urban, county safety-net hospital established a program to provide comprehensive medical aid in dying care via a centralized clinic with a dedicated team including a medical director, social worker, and a network of volunteer consultants. As the program has developed and matured, it has grown exponentially. This is due to its ease of accessibility, statewide educational efforts, and the relatively low cost and need-based, free services it provides. In six and a half years, our centralized program assisted over 650 Colorado patients in their quest for accessing medical aid in dying care, providing a wide continuum of services from initial intake and counseling, visits, and financial aid to specific grief counseling for loved ones. We believe our centralized system may function as a model for other hospitals considering the need to improve aid in dying access and care.

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Disparities in end-of-life care: A retrospective study on intensive care utilization and advance care planning in the Colorado all-payer claims database

04/26/25 at 03:00 AM

Disparities in end-of-life care: A retrospective study on intensive care utilization and advance care planning in the Colorado all-payer claims databaseAmerican Journal of Hospice and Palliative Medicine; Darcy Holladay Ford, PsyD, MA, LPC, RDN; Kimberly Landry, MPH; Megha Jha, MPH; Martha Meyer, PhD; 3/25Intensive end-of-life (EOL) care is emotionally and financially burdensome, disproportionally negatively impacting racial and ethnic minorities, rural residents, and lower socioeconomic seniors. ICU Stays: Hispanic/Latino, Asian, and Black members had increased ICU stays compared to Whites ... However, members without ACP [advance care planning] and rural residents had lower ICU stays ... ED Visits: Hispanic/Latino, Asian, Black members, non-dually eligible members (Medicare Fee for Service (MFFS) + Medicaid), and rural residents had increased ED visits ... Meanwhile, members without ACP or hospice care had lower ED visits ... 30-day Readmissions: Asian members and rural residents had increased 30-day readmissions ... In contrast, those on MFFS and not on Medicaid, members without ACP, and those not in hospice care had decreased 30-day readmissions ...

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Research study participation: Practice Analysis Study

04/26/25 at 02:05 AM

Research study participation: Practice Analysis StudyHMDCB email; 4/24/25The Hospice Medical Director Certification Board (HMDCB) is conducting a Practice Analysis Survey and we are seeking your help to gather physician feedback. If you haven't already, we encourage you to share this email with your hospice physicians/medical director and encourage them to participate.

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Research study participation: Have you been an unpaid caregiver to a hospice patient?

04/26/25 at 02:00 AM

Research study participation: Have you been an unpaid caregiver to a hospice patient?Press release, Northern Illinois University and Seattle University; M. Courtney Hughes, Erin Vernon; 4/23/25You may be eligible to participate in a new survey. Help us understand which services (e.g., meals, transportation) most positively impact hospice patients and their families.

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Research study participation: Have you been an unpaid caregiver to a hospice patient?

04/25/25 at 03:00 AM

Research study participation: Have you been an unpaid caregiver to a hospice patient?

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Advance care planning in the inpatient setting: The role of the hospitalist

04/19/25 at 03:40 AM

Advance care planning in the inpatient setting: The role of the hospitalistAmerican Journal of Hospice and Palliative Medicine; Nikhil Sood, MD; Rohini Garg, MBBS; Anthony D. Slonim, MD, DrPH, FCCM; 3/25Advance care planning (ACP) is critical to patient-centered health care, particularly in hospital settings where acute and end-of-life decisions often occur. As frontline providers, hospitalists are uniquely positioned to initiate and guide ACP discussions. This article explores the role of hospitalists in ACP, identifies barriers to its implementation, and highlights strategies to overcome these challenges. Key barriers include time constraints, lack of formal training, and uncertainty regarding the appropriate timing of discussions. To address these issues, hospitalists can benefit from structured communication training, integration of ACP prompts into electronic health records, and collaboration with multidisciplinary teams. While ACP has demonstrated benefits, including the alignment of care with patient preferences, reduced unnecessary interventions, and improved satisfaction for patients and families, challenges remain in ensuring consistent and culturally sensitive implementation.

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TIEC, trauma capacity, and the moral priority of surrogate decision makers in futility disputes

04/19/25 at 03:35 AM

TIEC, trauma capacity, and the moral priority of surrogate decision makers in futility disputesThe Journal of Clinical Ethics; Autumn Fiester; Spring 2025In the past 15 years, trauma-informed care (TIC) has evolved as a new paradigm in healthcare that recognizes the impact of past traumas on patients' and families' healthcare experience while seeking to avoid inducing new trauma during clinical care. A recent paper by Lanphier and Anani extends TIC principles to healthcare ethics consultation (HEC) in what they label "trauma-informed ethics consultation" (TIEC), which calls for the "addition of trauma informed awareness, training, and skill in clinical ethics consultation." While Lanphier and Anani claim that TIEC is "novel, but not radical" because it builds on the approach to HEC endorsed by the American Society for Bioethics and Humanities, I believe that TIEC has radical implications, particularly regarding ethical obligations to surrogate decision makers (SDMs). Given what I call the SDM's "trauma capacity," I argue that TIEC accords moral priority to SDMs over patients in certain types of end-of-life cases, particularly futility disputes, which is a radical departure from the conventional HEC approach to SDMs.

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The physical side of grief: Physical symptoms in bereavement

04/19/25 at 03:30 AM

The physical side of grief: Physical symptoms in bereavementIllness, Crisis and Loss; Crystal L. Weeden, Nora P. Reilly; 3/25Both emotional and physiological responses to loss are normal reactions to bereavement. The aim of the study was to examine if the type of loss someone experienced was related to the magnitude of their expressed symptomology in a nonwidowed specific sample. Specifically, to determine if there is a difference in physical symptoms between participants who experienced grief due to an out-of-order loss (a death before the age of 55) versus those who experienced grief after a natural life progression loss (a death that occurs after the age of 80). Results confirmed that those who bereaved an out-of-order loss experienced significantly more symptomology, both emotional and physiological, than those who lost a loved one aged 55 or older. This study highlights the importance of identifying those at the highest risk for increased grief-related symptomology.

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PEMF therapy: A non-invasive approach to enhance cancer treatment

04/19/25 at 03:25 AM

PEMF therapy: A non-invasive approach to enhance cancer treatmentHope 4 Cancer Treatment Centers; by Antonio Jimenez, Subrata Chakravarty; 2/25The Earth’s magnetic field, a constant presence in our environment, has a subtle yet profound impact on human health. Operating at extremely low frequencies and low intensities, it is generated by electric currents in the Earth’s conductive iron-rich core. This magnetic field serves as a protective shield, deflecting solar wind—charged particles from the sun— that could devastate life on Earth. Beyond its protective role, It also helps regulate circadian rhythms and supports cellular function. Our cells exist within this dynamic electromagnetic environment, and by harnessing its properties, we can actively enhance cellular health, physiological balance, and overall well-being.Publisher's note: Hope 4 Cancer is a naturalistic / neuropathic healing center in Mexico exploring innovative cancer treatments. Additional articles readers might be interested in include Treating cancer with sound waves: An overview of sonodynamic therapy and Modulated TRPC1 expression predicts sensitivity of breast cancer to doxorubicin and magnetic field therapy: Segue towards a precision medicine approach.

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Prevention of opioid misuse and abuse through effective pain management in patients with chronic pain: An umbrella systematic review

04/19/25 at 03:20 AM

Prevention of opioid misuse and abuse through effective pain management in patients with chronic pain: An umbrella systematic reviewCureus: Sana Sultana, Safeera Khan; 3/25Chronic pain is a condition that affects physical well-being as well as emotional well-being, has mental impacts on patients, and diminishes their quality of life. There is also growing evidence that opioids have only limited effectiveness in the management of CNCP [chronic non-cancer pain], and the increased availability of prescription opioids has contributed to an increase in opioid addiction cases and overdose deaths. This review was conducted to determine if adequate pain management would decrease opioid use and prevent misuse. We discussed the different pain management methods in the paper, including the different pharmacotherapy options, nerve blocks, and spinal cord stimulation. We also talk about multidisciplinary treatment with the involvement of various departments (physician, pharmacy for pill counting, physical therapy, psychological care, etc.) in managing pain; good outcomes were observed with improvement in function.

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Appropriate deprescribing and payment in hospice dementia care

04/19/25 at 03:15 AM

Appropriate deprescribing and payment in hospice dementia careJAMA Internal Medicine; Nathan M. Stall, MD, PhD; Sharon K. Inouye, MD, MPH; Lona Mody, MD, MSc; 3/25People living with dementia are one of the largest growing users of hospice care in the US, with approximately 20% of enrollees having a terminal diagnosis of dementia. In the setting of advanced dementia specifically, guidelines recommend deprescribing cholinesterase inhibitors and memantine as there is insufficient evidence for benefit, and there are risks of adverse events including bradycardia, falls, and gastrointestinal adverse effects. The Centers for Medicare & Medicaid Services specifies that hospices are responsible for covering all medications under the Medicare Part A hospice benefit, but audits have revealed that millions of dollars of prescription drug costs are being inappropriately shifted to Medicare Part D. The study by Hunt et al occurs within a context of growing concerns about shifts in US hospice care where more than 70% of hospice agencies serving patients with terminal illness across all settings now operate on a for-profit basis, with increasing acquisition of hospices by private equity firms and publicly traded corporations. Compared with nonprofit hospices, for-profit hospices have more acute care utilization, provide less direct care, and have poorer caregiver-reported care experiences. For-profit hospices also enroll a higher proportion of persons living with dementia, which may relate to their lower acuity and longer stays, as well as more profitable margins under the per-beneficiary daily payment.

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Access to outpatient palliative care: Insights from Michigan

04/19/25 at 03:10 AM

Access to outpatient palliative care: Insights from MichiganAmerican Journal of Hospice & Palliative Care; by Andrew E Russell, Maria J Silveira; 4/25Outpatient palliative care provides supportive care to community-dwelling patients with serious illness who are not eligible or ready for hospice. Little is known about the services these clinics offer and the populations they serve. We conducted a cross-sectional study of outpatient palliative care clinics in Michigan to describe their services and identify gaps in care... There is limited access to outpatient palliative care in Michigan, especially in rural communities. Many clinics do not accept non-cancer or pediatric patients. Additionally, many clinics lack the full interdisciplinary team that is required to provide robust palliative care.

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Pacemaker and defibrillator deactivation in competent hospice patients: an ethical consideration

04/19/25 at 03:05 AM

Pacemaker and defibrillator deactivation in competent hospice patients: an ethical considerationAmerican Journal of Hospice and Palliative Care; by Jennifer M Ballentine; 1/05In 2003, a Colorado hospice provider asked the DCBC for assistance in developing a policy on deactivation of pacemakers and defibrillators in competent hospice patients. The hospice had encountered concerns from some physicians and cardiac care clinicians that deactivating such devices treads the fine line between legitimate withdrawal of burdensome treatment and assisted death... This article summarizes contributions from the committee's discussion, as well as independent research undertaken by the author.Publisher's note: This older, yet still relevant and helpful, article recently came across my desk.

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Quality of nonprofit hospice affiliated with integrated healthcare systems

04/19/25 at 03:00 AM

Quality of nonprofit hospice affiliated with integrated healthcare systemsJournal of Pain & Symptom Management; Gulmeena Khan, Emmanuelle Belanger, Joan Teno; 4/25Research shows hospice primary caregivers report better quality of care at Nonprofit (NP) than For-Profit (FP) hospices, but there is variation in quality across NP hospices. CAHPs hospice scores did not differ if a hospice was part of integrated healthcare system or not. Further research is needed on variation in quality in NP hospices.

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Prospects for artificial intelligence in health policy and practice

04/12/25 at 03:45 AM

Prospects for artificial intelligence in health policy and practiceJAMA Health Forum; John Z. Ayanian, MD, MPP; Zirui Song, MD, PhD; 3/25Solving complex diagnostic challenges is a natural application of AI [artificial intelligence] in health care and a compelling way to benchmark its capabilities. The more extraordinary test of AI will be its ability to unravel the ordinary—the everyday needs and struggles faced by patients and clinicians. Which words and what tone should a clinician use to motivate a patient to smoke less, exercise more, or adhere to medications? In these routine, imperfect moments, when the science of medicine morphs into an art of trust, and that art is an inherently human endeavor of caring, how could AI help clinicians choose the words, body language, and tone to deliver better care? The mystery no longer resides in putting together puzzle pieces of data, but rather in piecing together emotions, intuition, and tradeoffs. Improved chronic disease management, more efficient use of societal resources, and better quality of life are among the potential pots of gold at the end of the AI rainbow.  

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Hiding in plain sight: A narrative review of non-parental relatives' perinatal grief

04/12/25 at 03:30 AM

Hiding in plain sight: A narrative review of non-parental relatives' perinatal griefJournal of Social Work in End-of-Life and Palliative Care; Rennie Bimman, Nancy Graham; 3/25Perinatal loss frequently leads to disenfranchised grief, and members of family systems less proximate to the loss are at risk for additional disenfranchisement. Grandparents and siblings are especially vulnerable to complications in perinatal grief due to intersecting and disenfranchising factors of identity, including age, role within family, and type of loss. Evidence found attested to the uniquely complex grief experiences these populations face as a result of their confluent disenfranchisement, and their overwhelming lack of support and recognition. New insights uncovered may inform clinicians as they assess needs and provide support to these oft-ignored grievers. Significant research gaps remain in this subtopic, such as firsthand perspectives of nonparental grievers, data on other extended family members, and the effect of additional psychosocial stressors on nonparental perinatal grief.

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Ambiguous loss: Implications for perinatal and neonatal nurses

04/12/25 at 03:25 AM

Ambiguous loss: Implications for perinatal and neonatal nursesNeonatal Network; Rachel A Joseph, Mary Highton; 3/25Ambiguous loss, a term coined by Pauline Boss, is a state in which there is no actual "death" and, therefore, no "grieving" or closure associated with it. Pregnancy is a happy event most of the time; however, the loss of pregnancy can be distressing to the parents. While the birth of a child is expected to be a joyful event, premature birth and subsequent admission to the NICU for prolonged periods with fluctuating conditions force the parent to be in a constant crisis mode where the outcome is unknown. This can mentally, physically, and emotionally drain the parents and may cause depression or other mental health challenges. Perinatal and neonatal nurses are uniquely positioned to recognize the warning signs of emerging grief crises in the parents and support them appropriately.

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Interventions for prolonged grief disorder in children and adolescents: A systematic review

04/12/25 at 03:20 AM

Interventions for prolonged grief disorder in children and adolescents: A systematic reviewJournal of Child & Adolescent Trauma; Sarah Bondy, Haleigh Scott; 3/25 Prolonged Grief Disorder (PGD) was added as a new diagnosis to the Diagnostic and Statistical Manual of Mental Disorders 5 Text Revision (DSM-5-TR). There is a need to tailor interventions to children and adolescent populations, but there is a lack of consensus on best practices for treating PGD in these populations. Interventions were grouped by modality including group treatments, hybrid treatments (combined group or individual therapy with family therapy), family treatment, and individual treatment. Cognitive Behavior Therapy (CBT), Attachment Theory and Multidimensional Grief Theory were common theoretical bases for interventions and all shared elements of psychoeducation and integrating knowledge about the loss with existing knowledge. Results for each intervention were found to be generally positive in reducing PGD symptoms.

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A mother’s goodbye-Barriers to microtransitions in care

04/12/25 at 03:15 AM

A mother’s goodbye-Barriers to microtransitions in careJAMA Internal Medicine; Aval-Na’Ree S. Green, MD, MHA, CMD; Benjamin E. Canter, OTD; 3/25After a long, debilitating battle with lupus, my cousin died at the doorsteps of our health system. The funeral was at 11:00 am. I arrived at the facility at 8:45 am. Although the catheter was in place, my aunt was undressed, with remnants of breakfast on her gown. She had not been bathed. The staff and I wheeled my aunt outside and attempted to load her into the van. Once my aunt was in the chair, it could not fit through the van door. Because this transition was not a medical health care appointment, the facility did not coordinate the resources, including use of the van, that were necessary for it to occur successfully. In contrast, had this been a medical outing, such as a weekend dialysis appointment, the facility would have been required to provide transportation. If this microtransition had been treated like a major health care transition, perhaps it would have had a better chance of success. Nursing teams use checklists during major care transitions; similar procedures should apply to microtransitions.

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“I Don’t Know What to Say”-A multimodal educational and environmental intervention to improve bedside nursing communication at end of life

04/12/25 at 03:10 AM

“I Don’t Know What to Say”-A multimodal educational and environmental intervention to improve bedside nursing communication at end of lifeJournal of Hospice & Palliative Nursing; Wolownik, Gregory DNP, AGPCNP-BC, ACHPN; Wholihan, Dorothy DNP, AGPCNP-BC, ACHPN, FPCN, FAAN; 4/25... research shows inpatient medical-surgical nurses are not adequately trained to deliver end-of-life (EOL) care. This lack of foundational learning leads to gaps when communicating with patients and families and negatively impacts quality of care. A literature review and staff interviews identified barriers to communication, such as lack of formal education and experience; personal, cultural, and emotional challenges; and high workload. A multimodal intervention focusing on improving staff nurse communication skills was designed ...[including] environmental cues, engaging pocket cards, and an education module on communication techniques. Nurses demonstrated increased confidence and competence immediately following the education session, enduring at 4 weeks. Innovative, clinically relevant interventions can positively impact communication skills without requiring increased time commitments or high cost.

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