An AI-powered lifestyle intervention vs human coaching in the Diabetes Prevention Program: A randomized clinical trial

An AI-powered lifestyle intervention vs human coaching in the Diabetes Prevention Program: A randomized clinical trial
JAMA Network; by Nestoras Mathioudakis, Benjamin Lalani, Mohammed S. Abusamaan, Mary Alderfer, Defne Alver, Adrian Dobs, Brian Kane, John McGready, Kristin Riekert, Benjamin Ringham, Aliyah Shehadeh, Eatmata Vandi, Amal A. Wanigatunga, Daniel Zade, Nisa M. Maruthur, for the AI-DPP Study Group; 10/27/25
How does referral to a lifestyle intervention exclusively driven by artificial intelligence (AI) compare with referral to a human coach–led Diabetes Prevention Program (DPP) lifestyle intervention? Among adults with prediabetes and overweight or obesity, a fully automated AI-led DPP may be a viable alternative to a DPP led by human coaches.
Publisher's note: This article caught my attention because I was certain "human coaching" would out-perform the "AI-powered lifestyle intervention". I was wrong - nearly equal percentages of participants achieved the primary weight loss outcome. We continue to explore strengths and weaknesses of AI...